There are usually three indicators of hepatitis B virus replication: the first one is hepatitis B surface antigen. The second is the hepatitis B e antigen. The third is hepatitis B DNA, which can most directly reflect hepatitis B virus replication is hepatitis B DNA, the level of hepatitis B surface antigen and hepatitis B e antigen, can indirectly reflect the state of hepatitis B virus replication. The higher the quantification of hepatitis B surface antigen, the higher the level of hepatitis B virus replication. The higher the level of hepatitis B e antigen, the higher the replication status of the hepatitis B virus. For hepatitis B virus carriers, these indicators need to be reviewed regularly, and regular follow-up of liver function, abdominal ultrasound, and alpha-fetoprotein are also needed. In the course of antiviral treatment, it is also necessary to monitor hepatitis B surface antigen, hepatitis B e antigen and hepatitis B DNA.