About 1/3 of HBsAg-positive people originate from their mothers, and HBsAg-positive mothers can transmit the virus to their fetuses or infants. So HBsAg positive mothers ask, can I have a baby? How can I have a healthy baby? Can I breastfeed? The answer is yes, HBsAg positive mothers can have healthy babies, and with proper treatment, HBsAg positive mothers can breastfeed. The modes of mother-to-child transmission are: intrauterine placental transmission, perinatal/natal transmission and postpartum transmission. Perinatal transmission, through exposure to body fluids and blood of HBsAg-positive mothers during delivery, is the main mode of mother-to-child transmission, so preventing and interrupting perinatal transmission is the key to having a healthy baby. The protection rate of neonates with hepatitis B vaccine alone to block mother-to-child transmission is 87.8%. The double blockade of hepatitis B vaccine and hepatitis B immunoglobulin combined with immunization after birth, as recommended by experts, can enable HBsAg-positive mothers to have babies with a 95-97% protection rate to block mother-to-child transmission. There are two specific methods of combined immunization: 1. Newborns should be immunized with hepatitis B immunoglobulin as early as possible within 24 hours after birth, preferably within 12 hours, and the dose should be ≥100 IU, along with 10 micrograms of recombinant yeast or 20 micrograms of Chinese hamster eye oocyte hepatitis B vaccine at different sites. 2. Newborns should be given 1 dose of hepatitis B immunoglobulin within 12 hours after birth and a second dose of hepatitis B immunoglobulin 1 month later, together with 1 dose of hepatitis B vaccine (at the same dose as before) at different sites, and a second and third dose of hepatitis B vaccine at intervals of 1 month and 5 months, respectively. The latter is less convenient than the former, but has a higher protection rate than the former.