Reproductive tract infection (RTI) is an infection caused by microorganisms normally present in the reproductive tract or by external microorganisms that enter the reproductive tract during medical operations or during sexual contact. Mycoplasma infection is a common sexually transmitted infection in women and is a difficult problem in clinical management. The treatment aspects of mycoplasma and chlamydia vaginitis are summarized below. 1. Pathogens The pathogens of mycoplasma infections include Mycoplasma humanum (MH), Mycoplasma urealyticum (UU) and Mycoplasma genitalium (MG). Mycoplasma solium has the highest rate of infection and can cause not only inflammation of the urinary tract and reproductive tract, such as non-gonococcal urethritis, vaginitis, cervicitis, endometritis, pelvic inflammatory disease, and in severe cases, infection in pregnant women, infertility, intrauterine growth retardation of the fetus, and a high recurrence rate and difficulty in treatment. 2, the means of transmission Mycoplasma exists in the vagina, around the urethra, the ectocervix and urine, mainly through sexual contact transmission. When a pregnant woman is infected, it can be transmitted vertically through the placenta. In the process of delivery, it can also infect the fetus through the contaminated birth canal. Clinical manifestations In women, the infection is often found in the cervix and then invades the vagina, leading to mycoplasma vaginitis. Mycoplasma vaginitis is an inflammatory disease of the reproductive system that spreads around the cervix. When the infection spreads to the urethra, urinary frequency and urgency are the main symptoms that attract the patient’s attention. When the infection is confined to the cervix, the symptoms are increased leucorrhea, cloudiness, edema, congestion or surface erosion of the cervix. If the infection spreads to the urethra, the urethral orifice is flushed and congested, and a small amount of discharge can be spilled by squeezing the urethra, but pressure pain is rarely present. A common comorbidity of mycoplasma infection is tubal inflammation, and a few patients may develop endometritis and pelvic inflammatory disease. 4. Diagnosis Mycoplasma culture: remove vaginal and cervical secretions with sterile cotton balls, insert a sterile cotton swab 1 to 2 cm into the cervix and gently rotate to remove the secretions containing columnar epithelial cells. Since mycoplasma lacks a cell wall, β-lactam antibacterial drugs that inhibit cell wall synthesis are ineffective, and mycoplasma infections are often slow and prolonged, the correct choice of drugs is essential for a cure. Generally speaking, the sensitivity rate of cross-trimoxazole, doxycycline and memantine to mycoplasma is above 90%, and they are the main antibiotics for the treatment of mycoplasma. If necessary, antibiotics can be selected according to the results of the drug sensitivity test. 6, pregnancy combined with mycoplasma infection The preferred treatment drug is azithromycin 1 g in doses, alternative therapy is erythromycin 0.5 g/bid orally for 14 days. The husband should be treated at the same time and a condom should be used during treatment.