When the Down’s syndrome test result shows high risk, non-invasive DNA testing or amniocentesis can be performed. It is usually recommended that non-invasive DNA testing be performed first, and if the result still shows high risk, then amniocentesis should be performed further. Both have their own advantages and disadvantages, need to weigh the pros and cons of the choice under the guidance of the doctor: 1, non-invasive DNA testing: mainly through the extraction of pregnant women’s serum for testing, according to the age of the pregnant woman, height, weight and gestational weeks of the comprehensive analysis, to detect the number of chromosomes whether the number of abnormalities, in order to assess and determine the risk of fetal trisomy 21 disease. The advantages are less traumatic, suitable for most women, and will not cause damage to the fetus, so this method can be preferred when the result of Down screening test is high risk; 2. Amniocentesis: amniocentesis needs to pass through the uterine wall to extract the amniotic fluid for examination, and the result of the examination is more accurate than the non-invasive DNA test, but there is a certain degree of trauma, and the pregnant woman needs to take a rest for 3-4 days after the examination, which is usually of less impact, and can be accepted by most patients, but in a very few cases, it can be accepted. Usually, the effect is small and most patients can accept it, but in rare cases, uterine infection or miscarriage may occur.