Amniocentesis is one of the most important tests as prenatal screening and is important in reducing the number of children born with congenital stupidity, dementia and other such congenital defects. It is of indelible significance in reducing the burden on families and society. Amniocentesis, as an invasive test, is not necessary for all pregnant women. Generally speaking, amniocentesis is recommended for pregnant women who are over 35 years old, at high risk for Down’s syndrome screening or who have had a history of chromosomal abnormality in childbirth. In fact, amniocentesis is not as scary as pregnant mothers think, it is like a regular intramuscular injection, but for pregnant women with fever, preeclampsia, and an overly sensitive uterus, there is a risk of infection and miscarriage. For the fetus, amniocentesis is performed under ultrasound localization, not “blind”, and the period of amniocentesis is also chosen to be a relatively small fetus and amniotic fluid is more, there is a large pool of amniotic fluid around the fetus, which greatly protects the safety of the fetus, and there are very few cases in which the puncture is stuck in the body of the fetus. In order to minimize the risk of amniocentesis, it has strict contraindications, after all, we are only there to screen for risk. For example, amniocentesis will not be performed on patients who have had a prior miscarriage, have a temperature higher than 37.5 degrees Celsius, have signs of pelvic or uterine infections, have a tendency to bleed or have blood clotting abnormalities until they are in optimal physical condition. It should be reminded that although amniocentesis is simple and easy to perform, it is an invasive procedure and inevitably involves some risks. Amniocentesis is not mandatory, but for the sake of the health of the next generation, doctors recommend amniocentesis to avoid future regrets.