Whether to do non-invasive DNA prenatal screening or amniocentesis after pregnancy has now become the heartbreak of many pregnant women, let me share my opinion: 1. The fact that Down’s syndrome is not hereditary and occurs randomly means that every fetus should have Down’s syndrome prevention. The gold standard for Down syndrome prevention in our country is amniocentesis, which has an accuracy rate of nearly 100%. The main method of prenatal diagnosis is amniocentesis, while low risk does not require amniocentesis. 5.Serological screening is usually not recommended for pregnant women older than 35 years old in our country, and amniotic fluid sampling is directly recommended. 6.There are two problems with Down’s serological screening: first, the high rate of false positives, our center an average of 40-50 pregnant women with high risk of Down’s only one real pregnancy with Down’s syndrome, other pregnant women have drawn a needle in vain; second, there are false negatives, our center has encountered many patients with Down’s syndrome after birth to do the test, a considerable number of pregnant women are done Down’s serological screening, but for low risk, on This is the most frightening false negative. The majority of pregnant women in our center over 35 years of age have their amniotic fluid drawn directly, and the majority of these pregnant women are carrying normal fetuses. 8. Non-invasive prenatal screening also draws the blood of the pregnant woman, but the blood is fetal DNA, which is different from the nature of serological Down’s syndrome screening. 9. Because the most serious chromosomal diseases of the fetus are the above three, and many unnecessary amniocentesis is avoided, our country now allows non-invasive prenatal screening. 10. The study did have nothing to do with the operation and method, so non-invasive prenatal screening can also have false negatives and is unavoidable, which is why non-invasive must sign an insurance contract 12. The National Health Planning Commission, in order to protect the interests of pregnant couples and to protect medical institutions In order to protect the interests of pregnant couples and to protect the legitimate rights and interests of medical institutions, the market of non-invasive DNA prenatal screening was rectified in 2014, and some medical institutions were allowed to carry out non-invasive prenatal diagnosis from January 15, 2015 13. I personally think that if you are at high risk for Down’s syndrome screening or an older pregnant woman, the effect of non-invasive DNA prenatal screening and amniocentesis is comparable, and it is better to do non-invasive DNA prenatal screening. Do not hope that the doctor, in this issue, the choice is up to the pregnant couple 16, non-invasive DNA prenatal screening is not a diagnosis, if non-invasive screening is a high risk, must do amniocentesis, the cost is free, must not directly induce labor 17, our hospital’s non-invasive DNA prenatal screening cost: 1950 yuan, 3 weeks to guarantee the report, our hospital’s amniocentesis cost: 1940 yuan (including chromosomal The report of all chromosomal conditions will be available in 3-4 weeks. Prenatal Diagnostic Center for Genetic Diseases, The First Affiliated Hospital of Zhengzhou University Address: Prenatal Diagnostic Center, 2nd Floor, Outpatient Building Tel: 0371-66913236 (Monday to Friday all day, Saturday morning, except holidays)