Whether to do non-invasive DNA prenatal screening or amniocentesis after pregnancy has now become the heart disease of many pregnant women, to talk about my opinion: whether non-invasive DNA prenatal screening or amniocentesis, the main purpose is only one, is to prevent the birth of Down syndrome, that is, the birth of a child with trisomy 21, Zhengzhou University, First Affiliated Hospital, Center for Genetics and Prenatal Diagnosis, Kong Xiangdong, no matter who may have a child with Down syndrome, and there is no family history, Down syndrome is not hereditary, it is a random occurrence, so every fetus should be prevented. The family history has nothing to do with it, Down syndrome is not hereditary, it occurs randomly, so every fetus should be prevented from Down syndrome Our country’s current gold standard for Down syndrome prevention is amniocentesis, which can be close to 100% accurate Currently, our country’s pregnant women under the age of 35 years are using Down’s serological screening to estimate the risk of the fetus being Down syndrome, and a high risk usually requires further diagnosis, the main method of prenatal diagnosis is Down’s serology, which can be used to detect Down syndrome in the fetus, and the risk of the fetus being at high risk is also high. The main method of prenatal diagnosis is amniocentesis, while amniocentesis is not required for low risk. In our country, serologic screening is usually not recommended for pregnant women older than 35 years old, and amniocentesis is recommended directly. There are two problems with Down’s serologic screening: first, the rate of false positives is high, and on average, we have seen 40-50 women with high risk of Down’s syndrome in our center before one of them is actually pregnant, and the other pregnant women have had a wasted amniocentesis; and second, there are false negatives. Secondly, there are false negatives. Our center has encountered many patients with Down’s syndrome who were tested after birth, and quite a number of pregnant women were screened for Down’s serology but were not further diagnosed because they were low-risk, and this is the most frightening false negative. Our center over 35 years of age of pregnant women directly draw amniotic fluid, there is also a vast majority of pregnant women pregnant with a normal fetus, these pregnant women draw amniotic fluid belongs to the accompanying crime non-invasive prenatal screening is also to draw the pregnant woman’s blood, but check the fetal DNA, and serological Down’s screening is of a different nature non-invasive prenatal screening for trisomy 21, trisomy 18, trisomy 13 detection rate is comparable to that of the detection of the amniocentesis, as the The most serious chromosomal diseases in fetus are the above three, and also avoid many unnecessary amniocentesis, so our country now allows non-invasive prenatal screening Because there are still some sex chromosome abnormalities and other diseases can not be detected, so the scope of non-invasive prenatal screening is not as large as the scope of the amniocentesis test Non-invasive prenatal screening for trisomy 21, trisomy 18, trisomy 13 test, the international community has done less than 1 million cases of non-invasive prenatal screening. Less than 1 million cases of non-invasive prenatal screening, also appeared about 10 cases of Down syndrome fetal missed diagnosis, the study is indeed not related to the operation and method, so non-invasive prenatal screening will also appear false negative, and inevitable, this is why non-invasive must sign the insurance contract of the National Health Commission in order to protect the interests of the pregnant couples, and also in order to protect the legitimate rights and interests of health care institutions, in 2014, on non-invasive In order to protect the interests of pregnant women and couples, as well as to protect the legitimate rights and interests of medical institutions, the National Health and Planning Commission in 2014 rectified the non-invasive DNA prenatal screening market, and allowed some medical institutions to carry out non-invasive prenatal diagnosis from January 15, 2015 The First Affiliated Hospital of Zhengzhou University’s current non-invasive DNA prenatal screening program is in full compliance with the requirements of the National Health and Planning Commission, and is legal and compliant, so it can be assured that non-invasive prenatal screening can be carried out in the hospital for non-invasive prenatal screening. I personally believe that if you are a high-risk Down’s syndrome patient or an older pregnant woman, non-invasive DNA prenatal screening and amniocentesis are equally effective, and non-invasive DNA prenatal screening is better. If you really can’t decide, do amniocentesis because after all, amniocentesis is the gold standard, and if you’re not willing to do it, just cast lots, and don’t count on the doctor. DNA prenatal screening is not a diagnosis, if the non-invasive screening is high-risk, must do amniocentesis, the cost is free, never directly induced Our non-invasive DNA prenatal screening cost:$1950, 3 weeks to ensure that the report, our amniocentesis cost:$1940 (including the cost of chromosome analysis), 5 working days to inform the fetus is not Down’s syndrome, 3-4 weeks to produce all the Chromosome report Prenatal Diagnostic Center for Genetic Diseases, The First Affiliated Hospital of Zhengzhou University Address: Prenatal Diagnostic Center, 2nd Floor, Outpatient Clinic Building Consultation Tel: 0371-66913236 (All day Monday-Friday, Saturday mornings, except holidays)