Hand, foot and mouth disease can be used externally to stop itching, such as glycerine lotion, mild itching usually do not need oral antipruritic drugs. Important treatment is antiviral drugs such as acyclovir tablets and other treatments, if co-infection with mupirocin ointment topical application, such as itching is obvious can be taken orally loratadine syrup. Hand, foot and mouth disease is an infectious disease caused by enterovirus, which has been occurring sporadically throughout the world in recent years. It is highly prevalent in spring. The disease is common in infants and young children, and preschool children. Can cause fever and hands, feet, mouth, buttocks and other parts of the rash, the general prognosis is good. Individuals can cause serious complications such as myocarditis, pulmonary edema, and aseptic meningoencephalitis. The itching caused by herpes in HFMD is in the vast majority of cases mild and can be relieved by topical glycerite lotion. It is important to treat with antiviral drugs such as acyclovir tablets. If the infection is combined with scratching, mupirocin ointment can be applied externally. If individual differences, itching is obvious, can be under the guidance of the doctor oral loratadine syrup and other antihistamines, has the effect of stopping itching. It is recommended that the emergence of hand, foot and mouth disease in a timely manner hospital consultation, follow the doctor’s instructions for treatment, do not self-medication.