The clinical manifestations of sepsis vary with the type, number and virulence of the causative organism as well as the age and resistance of the child. In mild cases, there are only general symptoms of infection, while in severe cases, infectious shock, DIC and multi-organ failure may occur. Clinical symptoms and manifestations of sepsis 1. Most of the symptoms of sepsis start rapidly, with chills or chills, followed by high fever, variable fever, flaccid fever or retention fever; weak, severely malnourished and small infants may have no fever, or even lower than normal body temperature. Mental depression or restlessness, or in severe cases, pale or blue-gray face and confusion. The end extremities are cold, shortness of breath, accelerated heart rate, decreased blood pressure, and jaundice may also appear in infants and children. 2. Skin lesions Some children may have various skin lesions, including petechiae, petechiae, scarlet fever-like rash, and zonular rash. The rash is commonly found on the skin of the extremities, trunk or oral mucosa. Petechiae or petechiae of varying sizes can be seen in meningococcal sepsis; scarlet fever-like rash is common in streptococcal and staphylococcus aureus sepsis. 3. Intestinal symptoms There is often vomiting, diarrhea, abdominal pain, and even vomiting blood and blood in stool; in severe cases, toxic intestinal paralysis or dehydration and acidosis may occur. 4.Joint symptoms Some children may have swollen and painful joints, impaired movement or fluid accumulation in the joint cavity, mostly in large joints. 5.Splenomegaly It is common in infants and young children, with mild or moderate enlargement; some children may be complicated by toxic hepatitis; when liver abscess caused by migratory damage of Staphylococcus aureus, liver pressure pain is obvious. 6, other symptoms Severely ill children often have myocarditis, heart failure, confusion, drowsiness, coma, oliguria or anuria and other symptoms of parenchymal organ involvement. Staphylococcus aureus sepsis is commonly associated with multiple migratory lesions; Gram-negative sepsis is often complicated by shock and DIC. petechiae, petechiae, pus, cerebrospinal fluid, thoracoabdominal fluid, etc. can also be directly smear and microscopic examination to find bacteria.