Sepsis (septicemia) used to be defined as a serious systemic infection caused by the entry of pathogenic organisms into the bloodstream, where they multiply and produce toxins. In recent years, research on sepsis has focused more and more on the systemic response of the body to microorganisms and their toxins, and the systemic response of the host to microbial infection is called sepsis (septicemia), which includes all microorganisms that cause human infections. The systemic inflammatory response to various damages, including bacterial infections, is called systemicinflammatoryresponsesyndrome (SIRS). The new definition of sepsis refers to the entry of microorganisms into the blood circulation and multiply in it, producing toxins and SIRS. What are the common symptoms of sepsis 1. Symptoms of infection poisoning: most of them start rapidly, first with chills or chills, followed by high fever, variable fever, flaccid fever or retention fever; frail, severely malnourished and small infants may have no fever, or even a body temperature below normal. Mental depression or restlessness, severe cases may appear pale or blue-gray face, confusion. Cold extremities, shortness of breath, increased heart rate, decreased blood pressure, infants and children may also appear jaundice. 2. Skin injury: Some children may have various skin injuries, including petechiae, petechiae, scarlet fever-like rash, and urticaria-like rash. The rash is commonly found on the skin of the extremities, trunk or oral mucosa. Petechiae or petechiae of varying sizes can be seen in meningococcal sepsis; scarlet fever-like rash is common in streptococcal and staphylococcus aureus sepsis. 3. Gastrointestinal symptoms: vomiting, diarrhea, abdominal pain, and even vomiting blood and blood in stool are often present; in severe cases, toxic intestinal paralysis or dehydration and acidosis may occur. 4.Joint symptoms: Some children may have joint swelling and pain, mobility disorders or joint cavity effusion, mostly seen in large joints. 5. Hepatosplenomegaly: it is common in infants and young children, with mild or moderate enlargement; some children may be complicated by toxic hepatitis; when the migratory damage of Staphylococcus aureus causes liver abscess, the liver pressure pain is obvious. 6, other symptoms: seriously ill children are often accompanied by myocarditis, heart failure, confusion, drowsiness, coma, oliguria or anuria and other symptoms of parenchymal organ involvement. The sepsis of Staphylococcus aureus is commonly associated with multiple migratory lesions; Gram-negative sepsis is often complicated by shock and DIC. petechiae, petechiae, pus, cerebrospinal fluid, thoracoabdominal fluid, etc. can also be directly smear and microscopic examination to find bacteria.