(Disclaimer: This article is for general use only. To protect patient privacy, the information in the following content has been processed.) Abstract: A 74-year-old aunt Zhou had previous pancreatic cancer surgery and repeatedly visited the hospital for postoperative recurrence of the lesion with abdominal distension, abdominal pain and jaundice. The family informed that the general condition outside the hospital was poor, and this time the patient visited the hospital because of poor appetite and anal cessation. [Basic information] Female, 74 years old [Type of disease] Sepsis [Hospital] The First Affiliated Hospital of Xi’an Jiaotong University [Date of consultation] January 2021 [Treatment plan] Intravenous infusion (piperacillin sodium tazobactam sodium for injection, cefminoxime sodium for injection, linezolid glucose injection) + oral medication (cefradine capsule) [Treatment period] Hospitalization for 8 days, out-of-hospital medication for 3 weeks. The patient’s symptoms of poor circulation and anemia were well controlled. The patient was told by his family that he had previously suffered from pancreatic cancer and had undergone surgery, which was relatively successful. I first examined the patient, and it was clear that the breath sounds of both lungs were coarse but no dry and wet rales were heard, and no heart valve murmurs were heard. A surgical scar of about 10 cm in length could be seen in the upper abdomen, and a hard, poorly defined mass with mild pain could be palpated. The patient had hyperactive bowel sounds but no lower limb edema. The initial diagnosis was sepsis. After communication with the family, the patient agreed to further examination and treatment, and was admitted to the hospital. II. Treatment After admission, the patient was prescribed a CT scan of the abdomen, which showed a possible right adnexal cyst, postoperative changes in the gallbladder and pancreas, and multiple nodules in the abdominal cavity, with metastasis considered. The CT scan of the chest showed partial bronchial dilatation in the upper lobe of the left lung and the lower lobe of the right lung, and a small amount of fluid in the right pleural cavity. He was diagnosed with postoperative pancreatic cancer and chronic cholecystitis. The patient was diagnosed with sepsis because the jaundice was worse than before and the fever was combined. After discussing with the family, it was decided to change the treatment drug and use cefminox sodium for injection combined with linezolid glucose injection for anti-infection and nutrition treatment. At the request of the family and the patient, the patient was discharged from the hospital with cefradin capsules to continue anti-infection treatment. III. Treatment effect After admission, anti-inflammatory and anti-infective treatment with piperacillin sodium tazobactam sodium for injection was carried out for 5 days, but no significant relief of febrile symptoms was observed. Therefore, the treatment was replaced with cefminoxime sodium for injection and linezolid glucose injection, and the febrile symptoms were better controlled. The patient was discharged with clear consciousness, no fever and symptoms of chills or abdominal discomfort, and the infection was considered to be better controlled in vivo, and the situation of poor nausea and anal exhaustion was improved compared with before. The patient was reviewed after 3 weeks of out-of-hospital medication and had no fever symptoms. I was very glad to see that the patient’s symptoms improved, but I did not forget to advise the patient and his family to pay attention to the following matters: 1. After discharge, we should increase nutrition, pay attention to eating high-protein food, such as milk, sea cucumber soup and other liquid diet, avoid eating hard and indigestible food, and pay attention to keeping the abdomen warm, so as not to induce abdominal distension and abdominal pain, which is not good for health; 2. During the period of taking medicine at home, family members should remind the patient to take medicine regularly to control the symptoms of infection and avoid fever. In this case, the patient was old and did not follow the medical advice to take medication regularly after cancer surgery, and the disease spread and metastasized due to the lack of timely medical review, which induced inflammation and infection and led to sepsis, which reminded us to tell the patient to take medication regularly. The benefits of taking medication regularly can lead to a better quality of life and a longer life expectancy. The daily occurrence of persistent abdominal discomfort should be promptly examined by a doctor to achieve early detection and treatment of the disease, so as not to delay the disease and make treatment more difficult.