Sepsis is the leading cause of death in burn patients. Low body resistance and bacterial infection are the two main factors contributing to the development of sepsis. The most common bacteria causing sepsis are Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Bacterial invasion into the bloodstream occurs through wounds, the mucosa of the digestive tract, the mucosa of the urinary tract, and venotomy tubes. How to check and diagnose burn sepsis? Diagnostic basis 1. Sudden rise in body temperature 39.5-40°C or paradoxical drop. Increased heart rate > 140 beats / min, fast breathing, who can not be explained by other reasons. Psychiatric symptoms such as irritability, delirium and hallucinations. Loss of appetite, bloating or diarrhea. The tongue turns from red to reddish-red, dry with little fluid and awned, the tongue moss turns from white and greasy to yellow or burnt, or the tongue is red and cracked, and the tongue moss is little and light peeling. 2.Wound deterioration. Scorched scabs become moist or deep Ⅱ ° scabs appear under the punctate hemorrhage or rupture of the overflow point, the number of which is increasing or gradually expanding. The granulation wound surface is gray, uneven, with dark red pitting necrosis. The viable skin fragments are eroded in the form of islands, which are not enlarged but shrunken. 3.White blood cell count increases or decreases, and toxic particles increase. Platelet count decreases and hypoproteinemia is present. Blood culture has pathogenic bacteria growth. According to the above symptoms and signs, early diagnosis can be made without waiting for the results of blood culture, so as not to miss the treatment. The diagnosis of enzyme bacteria sepsis is based on the following: a history of decreased systemic resistance, longer use of antibiotics or deep vein intubation, and growth of enzyme bacteria in the oral cavity, gastrointestinal tract, or on wounds. Severe symptoms of systemic toxicity, trance persistent high fever, nausea, loss of appetite, abdominal distension. Increased frequency of stools with mucus black stools. Urine and feces are seen with large numbers of enzyme bacteria. Blood cultures, wound cultures or tissue cultures show enzyme bacteria.