Allergic subseptic disease, also known as adult septicemia, is a relatively rare syndrome, with children being the most common. Its clinical features: rapid onset, mainly with prolonged persistent or intermittent fever; recurrent transient rash; wandering joint pain and lymph node enlargement, hepatosplenomegaly; markedly increased peripheral blood leukocytes, leftward nuclear shift, increased sedimentation, negative blood cultures; antibiotic therapy is ineffective, corticosteroids can relieve symptoms, but symptoms can often recur when reducing or stopping hormone use. Chinese medicine treatment can be found in the reference materials. [Fever: seen in 98%-100% of patients, is the most common and earliest symptom, with flaccid fever, about half of the chills before fever, can last for days to years, recurrent, antibacterial agents are ineffective, hormones or NSAIDs are effective. Most patients are in good self-conscious condition and have no obvious toxic symptoms, although they have prolonged fever. 2, rash: seen in more than 85% of patients, red pressure of fading, sometimes mild itching, easily confused with drug rash, more day and night, koebner phenomenon, fading without leaving traces, a few left pigmentation. 3, joint and muscle symptoms: the incidence of arthralgia and arthritis 87%-98%, 1/3 only show joint pain. Swollen joints with fever and dysfunction account for 2/3 of the cases, mostly involving the knee and wrist. Muscle pain accounts for about 80%, and fever is accompanied by muscle aches and pains, mostly without muscle enzyme elevation. 4, sore throat: seen in 50% of patients, fever with sore throat accounted for 64%, mostly in the early appearance, do throat swab culture negative, antibacterial agent is not effective. 5.Lymph node enlargement: seen in 44%-81% of patients, there may be generalized lymph node enlargement in early stage, and biopsy is mostly reactive hyperplasia. 6. Liver and spleen enlargement: liver enlargement is seen in 33%-39% of patients, spleen enlargement is seen in 50%-95% of patients, and 3/4 of patients have abnormal liver function. 7, other clinical manifestations: pleurisy, pericardial effusion, myocarditis, pneumonia. renal, central nervous abnormalities and peripheral nerve damage. [Blood and bone marrow tests: elevated white blood cells and neutrophils: generally (10-20) × 109/L, up to 50 × 109/L. Anemia: 90%-100% mostly hypochromic anemia. Platelets are elevated in 50%. Bone marrow images are easily seen as toxic particles and are easily reported as infected bone marrow images. Bone marrow culture is negative. 2. Elevated serum ferritin: positively correlated with disease activity, seen in more than 80%, can be used as a reference point for this disease, with sensitivity specificity of 74.8% and 83.2%, respectively. 3. Increased blood sedimentation and elevated CRP. 4.Immunoglobulin may be increased. 5. Synovial fluid shows inflammatory changes. 6.Blood culture is negative.