The treatment of Mycoplasma pneumoniae infection, cough without fever in children can be categorized into general treatment and medication. Mycoplasma pneumoniae is a microorganism between bacteria and viruses, without cell wall structure. After infection, cough is the prominent manifestation, at first dry cough, and then persistent cough. Treatment includes general therapy and medication. To ensure that the child rests, the room should be ventilated frequently, and maintain a certain temperature and humidity. The diet should be light and easy to digest, supplemented with enough vitamins. For Mycoplasma pneumoniae, macrolide antibiotics are preferred, and commonly used drugs include azithromycin and erythromycin. For severe coughing, which seriously affects daily life or sleep, dextromethorphan and cotrimoxazole can be used as prescribed by the doctor. Methylprednisolone, gammaglobulin, and bronchial lavage can be used for severe cases. All of the above medications should be used under the guidance of a doctor and avoid self-medication. When your child develops a cough and other discomforts, seek prompt medical attention and be evaluated and treated by a specialist to avoid delays in your child’s condition.