Cefixime and furotoxin can be taken at the same time for the treatment of glans and circumcision if the indications are met and contraindications are ruled out, but the specific use of the drug should be in accordance with the doctor’s instructions. Cefixime belongs to the cephalosporin antibiotics for streptococcus, gonococcus and other sensitive bacteria caused by urethritis, the drug is prohibited in the cephalosporin antibiotic allergy; furotoxin is a nitrofuran antibiotic for enterococci, staphylococcus bacteria, and other sensitive bacteria caused by the acute simple lower urinary tract infection, the drug is prohibited in the furain drug allergy or renal hypothyroidism. Currently there is no research to show that cefixime and furotoxin together will interfere with each other’s therapeutic effect, so if the glans and circumcision caused by the above sensitive bacterial infections and has ruled out the relevant contraindications, only from the point of view of the principle of action of the drug, it is possible to take these two drugs together for treatment. However, it should be noted that, according to the principle of antibiotic use, the clinic is generally recommended to carry out the treatment of a single drug (especially for the first time for those who use the drug), in order to observe the efficacy of the drug in the specific patient, if the effect is not good, and then consider changing the drug or adding drugs, and does not recommend directly for the combined use of the two antibiotics. In addition, it should be noted that cefixime may have adverse effects such as rash and diarrhea, while the adverse effects of furotoxin include nausea and headache. Therefore, the diagnosis of glans and circumcision, must be under the guidance of the doctor according to the actual situation of the choice and use of antibiotics, do not blindly use or increase or decrease the dosage of drugs, in order to avoid adverse consequences.