Hepatitis B surface antigen is greater than 1000IU/L, suggesting that the body is positive for hepatitis B surface antigen, indicating that it has been infected with hepatitis B virus. Hepatitis B surface antigen is a marker for detecting hepatitis B virus, and positive hepatitis B surface antigen indicates the presence of hepatitis B virus in the body, which requires complete hepatitis B virus DNA test, liver function, liver ultrasound and other related examinations to assess whether the hepatitis B virus is in replication status. If the quantification of hepatitis B DNA suggests that the hepatitis B virus is in an active stage of replication, antiviral treatment is needed, and commonly used drugs include entecavir, lamivudine, etc. If the liver function is abnormal and the transaminase level is high, the patient should be treated. If liver function is abnormal and aminotransferase is elevated, hepatoprotective treatment is needed, such as compound glycyrrhizin tablets and reduced glutathione. If liver function is normal, hepatitis B virus DNA quantification is low, and hepatitis B surface antigen is 1000IU/L, it means that hepatitis B virus carriers are more likely, and regular review is needed. It is recommended to consult a doctor, improve the examination, and follow the doctor’s instructions for treatment, so as to avoid the progression of the disease.