In response to the physician’s science, the main thing is also to remind yourself not to forget to give your patients prevention and reduce central lymphoma invasion! About 5% of patients will have a recurrence or invasion of central lymphoma, and individualized treatment must be applied to the patient. The following groups of patients are more likely to have central lymphoma invasion, and lumbar puncture sheath injection chemotherapy is recommended for prevention: elevated lactate dehydrogenase, and >1 extra-nodal invasion; 4 or more of the following risk factors, elevated lactate dehydrogenase; serum albumin <35 g/L, >60 years of age, retroperitoneal lymph node invasion; >1 extra-nodal invasion; lymph node invasion in some organs, such as the testes; bone marrow lymphoma invasion (equivalent to Acute lymphocytic leukemia are prevented as are lumbar puncture sheath injections of chemotherapeutic agents, whereas with the use of high-dose cytarabine, myeloid leukemia can be largely unprotected)