Leg pain for no reason like twisted, may be related to osteoporosis, may also be due to lumbar spine lesions, herpes zoster, osteosarcoma and other causes. 1. Osteoporosis: the elderly along with the age increase, the body in the reduction of bone mass, bone tissue structure of the slight destruction, resulting in a decline in bone strength, there may be a leg pain for no reason, like twisted. 2. Lumbar spine lesions: commonly seen in lumbar disc herniation, lumbar spinal stenosis and other diseases, which can easily lead to sciatic nerve root compression, which may cause radiating pain in the legs, and then cause pain in the legs, which may show pain in the legs for no reason, like twisting, and may be accompanied by numbness of the legs, numbness of the feet, lumbago and other symptoms. 3. Herpes zoster: usually caused by chickenpox and herpes zoster virus infection, when herpes zoster virus attacks on the sciatic nerve, it can lead to pain in the innervated area of the sciatic nerve, which may show pain in the leg for no reason, like twisting. 4. Osteosarcoma: when osteosarcoma disease occurs in the distal thigh, it is easy to cause damage to the local bone quality of the leg, which may cause pain in the leg for no reason, like twisting, and may be accompanied by restricted movement, swelling and other manifestations. The pain in the leg for no reason, like twisted, may also be caused by other reasons, if the symptoms continue to be unable to alleviate, you should consult a doctor as soon as possible to confirm the diagnosis of the causative factors and then give targeted treatment.