Cotrimoxazole, also known as cotrimoxazole, is a compound preparation of sulfamethoxazole and methotrexate. The hazards mainly include adverse drug reactions and toxic side effects after overdose. 1.Adverse reactions: ①Allergic reactions: rash, dermatitis, photosensitivity, drug fever, joint and muscle pain. ② gastrointestinal reactions: nausea, vomiting, diarrhea, loss of appetite. ③Hematological reactions: thrombocytopenia, granulocytopenia, anemia, hemorrhage, bilirubin encephalopathy. ④ Hepatic and renal impairment: jaundice, liver function impairment, drug hepatitis, nephritis, tubular necrosis, hematuria and tubular urine. ⑤ Nervous system: hallucinations, confusion, dizziness, disorientation. 2. Abdominal pain, nausea, vomiting, dizziness, headache, drowsiness and even coma may occur with overdose of Compound Sulfamethoxazole Tablets. Oral administration of cotrimoxazole needs to be standardized under the guidance of a doctor, allergic to this product, pregnant and lactating women, infants less than 2 months old, etc. This drug is prohibited, the emergence of maladaptation promptly consult a doctor.