Since birth, my baby has been having trouble passing stool. The first 2 days after birth, the baby did not pass fetal stool, the anus was normal, and the doctor instructed the baby to pass stool with corky, which resulted in more fetal stool being passed, but then the baby seldom passed stool on its own and needed to use corky to assist in defecation. Parents should be aware that their babies are suffering from congenital megacolon. The congenital megacolon, also known as ganglion cell-free disease, has no ganglion cells in the intestines (rectum and sigmoid colon), so it is in a spastic and narrow state and loses its normal peristaltic and defecation functions, and feces and intestinal gas accumulate in the proximal colon, resulting in secondary expansion and hypertrophy of the proximal colon and gradually forming a megacolon. Congenital megacolon is one of the more common developmental malformations of the gastrointestinal tract in newborns, accounting for the second highest incidence of gastrointestinal malformations, with a prevalence of 1/2000-1/5000, and is more common in males, with a familial tendency. Almost all normal newborns pass their first fetal stool within 24 hours after birth, and the first stool is excreted within 2-3 days. In children with congenital megacolon, the fetal stool cannot be passed because the intestinal canal is in a spastic and narrow state, so no fetal stool is excreted within 24-48 hours or only a small amount is excreted. The symptoms of partial or even complete low-level intestinal obstruction usually appear within 2-6 days: vomiting, which may be infrequent and small in amount, but may also be frequent, with bile or fecal-like liquid in the vomit; distended stomach, with full abdominal distension, some extremely distended and shiny belly. The symptoms are relieved by assisted laxation, but constipation, bloating and vomiting appear again after a few days. Due to recurrent episodes, children tend to show no weight gain. Complications such as small bowel colitis (with diarrhea), intestinal perforation, and malnutrition may also occur. Treatment of congenital megacolon includes non-surgical treatment, enterostomy, and radical surgery. Once diagnosed, radical megacolon surgery should generally be performed in order to cure it. Non-surgical treatment is suitable for mild cases, diagnosis is not fully determined and preparation for surgery, etc. The methods include: stimulating the anorectum with a cork, etc. to cause the child to defecate; using saline to wash the intestines, etc. Enterostomy is suitable for those with complications of small bowel colitis, intestinal perforation or poor general nutritional status. It is a transitional treatment measure, and about 1-2 months later, radical megacolon surgery is performed. In recent years, the age of radical megacolon surgery has been advanced from 1-2 years to 6 months after birth or even earlier, and more and more people are performing stage I megacolon radical surgery in the neonatal period, which can avoid complications such as small intestine colitis and malnutrition, and has achieved good results. In our hospital, we have adopted one-stage radical surgery in the neonatal period to reduce the inconvenience caused by conservative treatment of patients and to relieve the economic burden of parents and the psychological burden of waiting for surgery, and achieved good results.