Congenital megacolon, as it is called, is a disease characterized by the thickening of the wall of the large intestine due to the accumulation of stool in the large intestine caused by chronic constipation, resulting in a large colon. Congenital megacolon, also known as intestinal ganglion cell deficiency, is caused by the absence of ganglion cells at the end of the large intestine near the anal opening, which prevents peristalsis and defecation. So how do you differentiate megacolon from the common constipation? In terms of symptoms, most patients with megacolon have the following symptoms: delayed expulsion of fetal stool at birth, abdominal distention or vomiting, constipation before the age of 1 year, and inability to pass stool on their own unless they have an enema (whereas only one-third of patients with habitual constipation have these symptoms). Histopathological examination will be performed to help confirm the diagnosis. Children with megacolon cannot defecate on their own and have intestinal dysfunction, which seriously affects their growth and development. Therefore, once the diagnosis is established, the large intestine without ganglia must be surgically removed. With newer surgical concepts and the development of laparoscopic techniques, our surgeons will individualize your child’s design and choose the safest, most effective and aesthetically pleasing surgical procedure based on the specific condition. There may be a chance of bleeding and wound infection, but recovery is usually successful when performed by an experienced pediatric surgeon. After the surgery, parents should help their children to control their diet and develop bowel habits, and they can usually have a good quality of life.