Antidepressants have more side effects and can involve many systems, with symptoms such as gastrointestinal reactions, drowsiness, dry mouth, and constipation. Antidepressants are psychotropic medications used to treat depression by eliminating pathologically low mood and elevating mood. Common side effects are nausea, vomiting, diarrhea, dry mouth, constipation, etc. In severe cases, they can also cause neurological-type symptoms, such as headache, insomnia, fainting and tremor. However, these side effects do not affect the overall treatment and can basically be adapted. Depression in addition to drug treatment, there are psychotherapy, physical therapy, etc. According to different stages, it can be divided into acute treatment, consolidation treatment and maintenance treatment, each period of treatment is different, according to the different conditions, to adjust the treatment program. Depression drug treatment, need to be under the guidance of a professional physician.