The common factors causing enlarged spleen are spleen infection, splenic stasis, blood disease, connective tissue disease, etc. The treatment methods are different for different causes, including drug treatment and surgery, etc., which should be consulted in time. 1. Splenic infection: splenic infection can be seen in viral, bacterial, rickettsial and other infections, blood culture should be carried out, and anti-infection treatment should be carried out for the infected pathogens. 2. Splenic stasis: Splenic stasis is often seen in cirrhosis or right heart failure. Cirrhosis should be treated according to the cause of the disease; patients with right heart failure can be treated with volume expansion. 3. Hematological diseases: mainly seen in idiopathic thrombocytopenic purpura, hemolytic anemia, etc. Splenectomy is usually required. 4. Connective tissue disease: mainly seen in systemic lupus erythematosus, nodular polyarteritis, should be treated with hormones and immunosuppressants. It is recommended that the patient should visit the hospital in time and be treated under the guidance of the doctor to avoid delaying the condition.