A glomerular filtration rate of 45 ml/min for more than 3 months is generally indicative of stage III chronic kidney disease. Glomerular filtration rate is an important indicator for assessing renal function. In normal people, the glomerular filtration rate is ≥90 ml/min. and a glomerular filtration rate of 45 ml/min is generally indicative of stage III chronic kidney disease. Clinical manifestations of chronic kidney disease stage III include nausea, increased nocturia, fatigue, which may also be accompanied by mild anemia, pallor, decreased appetite, hypertension, etc. Treatment is mainly aimed at slowing down the progression of renal function, including actively treating the primary disease, controlling blood pressure, reducing proteinuria, preventing cardiovascular and cerebrovascular, and preventing and treating complications such as renal anemia. Glomerular filtration rate of 45ml/min, should promptly go to the hospital, improve the relevant examination, clarify the condition, under the guidance of a professional physician treatment.