Osteoporosis is a progressive systemic bone disease that can be primary or secondary; primary osteoporosis can be categorized as postmenopausal osteoporosis and senile osteoporosis, while secondary osteoporosis can be triggered by bone metabolic disorders, medication, or lifestyle (diet, smoking) factors. Clinical manifestations: Patients are usually unable to describe the clinical symptoms clearly; the main symptoms of acute osteoporotic spine fracture: (1) acute onset, usually with severe initial progression of the disease (2) severe localized girdle-like pain (3) a tearing sensation in the back, which is particularly severe when turning over in bed and sitting up. Fractures are usually associated with physical activity, but can be spontaneous. Imaging: (1) Two-dimensional examination of the relevant part of the body is still the choice of standing X-rays, and comparison with previous X-rays is valuable for diagnosis (2) MRI can detect fresh fractures Treatment: (1) Pharmacological treatment: Calcium, vitamin D, bisphosphonates, raloxifene, hormone replacement therapy, parathyroid hormone (2) Surgical treatment: vertebroplasty.