Pigmentation is mainly caused by the abnormal metabolism of melanocytes in the skin and the secretion of melanin. Most of the beauty seekers hope to achieve the purpose of removing spots through spot removal creams, but the effect is often poor, and long-term use of spot removal creams may also lead to: 1. allergic reaction: long-term use of spot removal creams may easily damage the skin barrier, causing skin thinning and sensitivity, resulting in capillary dilation, and in serious cases, papules and pustules may appear on the frequently applied parts. 2. Pigment loss: After some patients use it, it leads to the reduction of melanin cells, resulting in local pigment loss; 3. Chronic poisoning: The spot removal creams produced by unregulated manufacturers mostly contain heavy metals, such as mercury and lead. Mercury is a toxic heavy metal, which can damage pigment cells and reduce melanin production to achieve the so-called rapid spot removal and whitening. However, while mercury can remove spots and whiten the skin, it can also cause certain harm to human body. After mercury is absorbed into the body through the skin, it will damage the human nervous system, kidney, hematopoietic system, liver and reproductive system, causing infertility; for pregnant women, it will also affect fetal development through the placenta. If used for a long time, it will produce chronic toxic reactions; 4. Pigmentation: The chemical components in spot removal creams can produce photosensitive reactions after sunlight exposure, and pigmentation can appear at the application site.