Wrinkle reduction injections are a common and popular technique for micropigmentation. Commonly used injections include Botulinum Toxin Type A and Hyaluronic Acid. Wrinkle reduction injections are not a one-shot fix, one injection can last 6-8 months, and another injection is needed after six months. The hazards of wrinkle removal injection are small, but if the operator lacks professional knowledge improper operation, it may lead to the following hazards: 1. Local muscle dysfunction occurs, for example, when injecting the frontalis muscle, if the position is too low or the amount of injection is too much, it will lead to difficulty in raising the eyebrows, if the levator muscle is paralyzed, it will lead to difficulty in opening the eyes, but these conditions will gradually recover with the absorption of the injected agent; 2. If hyaluronic acid injection is applied If the injection is too shallow, nodules will be formed, and if it enters the blood vessels, it will lead to vascular embolism and serious skin necrosis; 3. If botulinum toxin injection is applied to remove wrinkles, it will cause botulinum toxin poisoning when the normal amount is exceeded, and the wrong injection site will cause more obvious harm, such as stiff facial expression, asymmetry, or the whole face is not coordinated. Therefore, it is recommended that beauty seekers should choose regular hospitals and qualified doctors for wrinkle removal injections in order to minimize the risk and protect the surgical effect.