The key to the treatment of septic shock is fluid resuscitation and the administration of strong anti-infective therapy, in addition to attention to the support of all organ functions. Fluid resuscitation is the key to sepsis treatment, and the goal of treatment is to maintain central venous pressure at 8-12 mmHg, mean arterial pressure greater than 65 mmHg, and urine output greater than 0.5 mL/kg/h. The patient’s lactate level should be observed during treatment, and volume assessment should be repeated for patients who do not reach the standard after resuscitation or whose lactate is greater than 4 mmol/L. Anti-infective treatment requires effective intravenous antibiotics within one hour, initially empirical anti-infection of choice, using all possible causative organisms, either single or multi-drug combination therapy, and once the pathogenesis is clear, step-down therapy can be considered. Others are organ function support, such as mechanical ventilation, continuous sedation, or hemofiltration or renal replacement therapy.