The causes of high creatinine are categorized into physiological and pathological causes. If the cause is physiological, it can be improved by removing the influencing factors and usually does not need special treatment. If the cause is pathologic, such as acute kidney injury, chronic renal insufficiency, etc., it is necessary to correct the cause of the disease in time, and give medication and dialysis treatment if necessary. 1. Physiological causes: some patients’ elevated creatinine may be caused by their high muscle content, or eating more meat and exercising more, if there is no abnormality in urine routine and ultrasound of urinary system, creatinine may return to normal after adjusting lifestyle, usually no special treatment is needed at this time. 2. Pathologic factors: (1) Pre-renal and post-renal acute kidney injury: pre-renal causes such as effective blood volume insufficiency, decreased cardiac output, etc. Post-renal causes such as prostate hypertrophy, tumor, etc. can make creatinine high, and the causes can be actively removed, such as rehydration and dilation, removal of obstruction, etc., which can bring creatinine down to normal. (2) Acute kidney injury, chronic renal insufficiency: such as acute tubular necrosis, acute interstitial inflammation and other acute kidney injury, or chronic renal insufficiency such as diabetic nephropathy, hypertensive renal damage, etc., active treatment of the underlying disease, the first choice of ACEI or ARB drugs such as captopril, valacyclovir, etc., dialysis treatment if necessary. All of the above medications should be used under the guidance of a doctor, avoid self-medication. If patients find that the blood creatinine is elevated, it is recommended that they go to a regular hospital in time and receive standardized treatment under the guidance of a doctor.