Carpal tunnel syndrome muscles appear to atrophy requiring surgical treatment. Carpal tunnel syndrome is a condition in which the median nerve is compressed and irritated in the carpal tunnel, resulting in clinical symptoms such as pain and numbness in the hand. When the median nerve is compressed for a long period of time, it can cause atrophy of the muscles at the level of the greater trochanter of the fingers, which affects the movement of the hand. Muscle atrophy usually occurs in the late stage of carpal tunnel syndrome, which should be treated surgically to relieve the compression of the median nerve and reduce the pressure of the carpal tunnel, so as to restore the nerve function, and the surgical methods mainly include endoscopic carpal tunnel release decompression and open carpal tunnel decompression. When muscle atrophy occurs in Carpal Tunnel Syndrome, it is necessary to consult a doctor as soon as possible and under the doctor’s guidance, surgery should be performed in order to restore hand function as soon as possible.