Fleas, bedbugs, lice, mosquitoes, bees and many other insect bites can cause human skin damage, often manifesting as redness, swelling, itching and other symptoms due to an acute local inflammatory reaction caused by toxins. First, it is recommended that local cold compresses with ice and 5% soda. Secondly, topical medication, such as redness, swelling and itching, but when there is no skin breakage, is recommended to use topical stove glycolic lotion. As the itching is more serious, after hand scratching the skin appears broken surface with exudate, it is recommended to apply topical 3% boric acid or 0.1% epsom saline solution topically, while it is recommended to apply topical mupirocin ointment topically 2-3 times a day. If the bite is red, swollen, itchy and heavy, while the area is relatively large, it is recommended to treat with topical hydrocortisone acetate ointment, mometasone furoate cream and other glucocorticoids.