Metastasis of different organs can occur in the late stage of lung cancer, which can cause corresponding symptoms and often bring great pain to patients and even threaten their lives. The most common clinical metastases are as follows: 1. Lung cancer brain metastases The unexplained headache, vomiting, visual impairment and personality and temperament changes of lung cancer patients may be caused by intracranial hypertension or brain nerve damage caused by lung cancer metastasis to the brain. It is commonly seen in small cell lung cancer and adenocarcinoma types. Headache is the most common symptom, vomiting mostly occurs when the headache is intense, characterized by jet vomiting; visual impairment indicates that the tumor has affected the compression or invaded the optic nerve. In addition to the above common symptoms, lung cancer brain metastasis may also present recurrence, paroxysmal black clouding, sudden collapse, impaired consciousness, increased blood pressure, slowed pulse, and in severe cases, brain herniation due to tumor compression may lead to respiratory arrest, endangering the patient’s life. In addition, due to the common application of brain CT examination for lung cancer patients in recent years, many patients with asymptomatic brain metastases have been detected, which has gained time for treatment. Therefore, brain CT should be included as routine examination for patients diagnosed with lung cancer to detect brain metastasis as early as possible. 2.Bone metastasis of lung cancer About 50% of lung cancer patients will eventually develop bone metastasis in multiple locations. Bone metastases are usually asymptomatic in the early stage, and bone isotope scan can detect the lesioned bones. The symptoms of bone metastasis are related to the location and number of tumor metastasis. For example, chest pain caused by lung cancer rib metastasis is mostly confined to the chest wall and has clear pressure points. Spinal metastases cause pain in the middle of the back or at the lesion site, while bone metastases in the extremities or trunk cause limited pain in that area. Bone metastasis is not the direct cause of life threatening lung cancer patients, but if the tumor metastasizes to the weight-bearing bones of the body, such as cervical, thoracic and lumbar vertebrae, it can cause serious consequences such as paralysis. Therefore, patients with bone metastasis from lung cancer should be treated in time. 3.Liver metastasis of lung cancer is also a common metastatic site of lung cancer, about 28-33% of lung cancer has liver metastasis. Liver metastasis is the invasion of primary lung cancer cells into the liver through blood circulation and growth in the liver. The most common symptom is pain in the liver area, which is persistent pain, and can be accompanied by loss of appetite, indigestion and other signs of impaired liver function. 4. Kidney and adrenal metastasis of lung cancer Kidney and adrenal metastasis are the result of blood metastasis in the late stage of lung cancer, about 17%-20% of lung cancer patients have kidney and adrenal metastasis, which are often asymptomatic. 5.Metastasis to other parts of lung cancer In addition to the above mentioned common metastases, the less common metastases include metastases to skin, subcutaneous tissues, muscles, abdominal cavity, heart and other parts of lung cancer, and the symptoms are often related to the metastases. For example, metastasis to the heart may cause chest tightness, palpitation or even shortness of breath, syncope, heart rhythm disorder and other symptoms.