Chronic hepatitis B is one of the major diseases that affect human health and to some extent affects people’s life, study and social life. If not effectively treated, it can lead to recurrent hepatitis attacks, which in turn may lead to liver fibrosis, cirrhosis and liver cancer. Today, experts at home and abroad have formed a consensus on the treatment of chronic hepatitis B, which is to suppress the hepatitis B virus to the lowest possible level in order to reduce liver inflammation, prevent or slow down the progression of liver fibrosis and cirrhosis, reduce the occurrence of liver cancer, and improve patients’ life span and quality of life. Therefore, antiviral therapy has become the main treatment measure for chronic hepatitis B and should be administered whenever it is available. So, what should be done to prepare before antiviral treatment? 1, psychological preparation: This is the first and most basic preparation. For the time being, it is quite difficult to completely remove the hepatitis B virus from the body. Only by maximizing the hepatitis B virus suppression at the lowest level as a way to reduce recurrent liver inflammation and slow down the progression of liver disease. Therefore, the treatment of chronic hepatitis B is a long-term process, and we must be prepared for a “protracted war”. And during the treatment must be very good compliance, strictly follow the doctor’s orders, on time medication, regular follow-up. 2. Physical preparation: This is a necessary and important preparation. Not all people infected with hepatitis B virus need antiviral therapy. The best time for treatment is only during the immune clearance period, which is the period of active liver inflammation. This time should be captured in a follow-up visit with a medical professional. A comprehensive analysis is provided by laboratory and imaging tests and, if necessary, liver histological evaluation (liver puncture). Therefore, it is recommended that those with positive hepatitis B viral markers, or a family history of hepatitis B, should be reviewed regularly, at least every six months, even if their liver function is normal. In addition, since antiviral treatment is a long-term process and the effects of antiviral drugs on pregnancy and the fetus are not yet known, in principle, conception is not recommended during treatment. Therefore, if a woman of childbearing age (including her spouse) urgently wants to conceive and give birth in the short term, it is recommended that antiviral treatment be withheld for the time being. Consider again when the birth is over according to the condition. 3. Time preparation: Once you start antiviral treatment, you must follow the doctor’s instructions, adhere to the medication on time, follow up regularly and have virological and other relevant tests. During this process the doctor will observe the efficacy or side effects of the drug and can also adjust the treatment plan in time according to the results. It is not standard to stop or reduce the dosage easily or to interrupt the medication, which can easily lead to drug resistance, loss of the achieved therapeutic effect, risk of relapse, and difficulty in the selection of future drugs. Therefore, it is necessary to have good compliance. 4, economic preparation: This is inevitable and very objective preparation. Of course, it is not the most expensive drug that works best. For a particular individual, it is important to weigh multiple factors such as disease state, efficacy, side effects, course of treatment, and affordability to choose the most suitable drug for you. In this process, the patient has full participation and can communicate with your treating doctor to understand the purpose of the treatment you receive, the course of treatment, the method, possible adverse reactions, the approximate cost situation, etc., to choose the most suitable treatment. 5, other: to have a good life and eating habits, no alcohol, no smoking, reasonable rest. In short, chronic hepatitis B is curable, difficult to treat, and long-term. You must be prepared in all aspects before treatment in order to face it with ease.