Lung cancer in advanced stage is very serious and can be treated with targeted drugs, but genetic test should be done for screening, choosing suitable targeted drugs and using drugs under doctor’s guidance. Advanced lung cancer can be treated with targeted drugs. Targeted therapy is a very important therapeutic means in the process of lung cancer treatment, but targeted therapy needs to do genetic test to find the corresponding target point and choose the targeted drugs with appropriate target point. For example, gefitinib for EGFR gene mutation, crizotinib for ALK gene mutation or ROS-1 gene fusion. Targeted drugs combined with chemotherapeutic drugs may be more effective, and some targeted drugs are also effective for advanced lung cancer patients who have failed treatment. Patients should use drugs under the guidance of doctors in order to improve the prognosis.