Hepatic amyloidosis is easily confused with acute hepatitis, primary or secondary hepatocellular carcinoma, cirrhosis due to various causes, and hepatomegaly. Hepatic amyloidosis lacks specific clinical and imaging manifestations, and is easily missed or misdiagnosed. Differential diagnosis should be made with various liver diseases causing hepatomegaly, such as acute hepatitis, primary or secondary hepatocellular carcinoma, cirrhosis due to various causes, and hepatomegaly. Hepatic amyloidosis, also known as amyloid deposition, is a metabolic disease of the liver in which amyloid protein substances are deposited in the tissues. At present, the etiology and pathogenic mechanism of hepatic amyloidosis are not clear, and it is generally believed that it may be due to various causes of amyloidosis material infiltration between cells, or deposition along the reticulofibrillar scaffolding as well as deposition under the basement membrane of small blood vessels. The clinical manifestations of hepatic amyloidosis are diverse, so it is very easy to be confused with other diseases of the liver. It is recommended to improve the examination in time, and standardize the treatment after clarification in time, so as not to delay the condition.