Perimenopausal syndrome refers to a series of syndromes caused by the gradual decline or loss of ovarian function around the time of menopause, resulting in a decrease in estrogen levels, mainly due to phytodysfunction and metabolic disorders. Recent symptoms of low estrogen levels include vasodilatory symptoms: hot flashes, night sweats, and palpitations. In some people, hot flashes are accompanied by dizziness, headache, head pressure, panic, tinnitus, and increased blood pressure, especially systolic blood pressure or chest pressure, lasting from 1 to 15 minutes. Psychoneurological symptoms: irritability, nervousness, depression, anxiety, fear, memory loss, and insomnia. Long-term symptoms caused by low estrogen levels Genitourinary atrophy: Because of the atrophy of genitourinary organs in women due to estrogen deficiency, vaginal dryness, difficulty in intercourse, itchy vulva, urinary frequency and urgency, painful urination, stress incontinence such as coughing and laughing, difficulty in urination, recurrent urethritis, cystitis, vaginitis, discomfort in intercourse and decreased libido can sometimes occur. Cardiovascular diseases: hypertension, diabetes, coronary heart disease, obesity, hyperlipidemia, etc. Osteoporosis: low back pain, short stature, hunchback, fracture. Skin becomes dry, lax, itchy, hyperpigmentation, pigmentation, zou-lin growth and anthroposis-like feeling of skin.