For the causes of cough and sputum in the middle of the night, they are as follows: 1. Infectious diseases of the respiratory system: they are the most common causes, such as colds, acute pharyngitis, acute bronchitis, acute bronchitis, lung infections, acute exacerbation of chronic obstructive pulmonary disease, bronchiectasis combined with infection, interstitial lung disease combined with infection, and other infectious diseases. If it is a viral infection, antiviral treatment is usually given. If it is a bacterial infection, give antibiotic anti-infective treatment, commonly used are penicillin amoxicillin clavulanic acid potassium, cephalosporin cefuroxime, cefdinir, macrolide azithromycin. If the adult is older than 18 years old, you can also use quinolone antibiotics, such as levofloxacin mesylate tablets for treatment. 2, cardiovascular system diseases: such as heart failure, lying flat after the heart’s return blood volume increases, while causing acute exacerbation of heart failure, will cough, coughing pink foamy sputum or coughing white sputum, sputum more, this situation to go to the emergency room, through the strong heart, coronary expansion, diuretic way to carry out Treatment.