Creatinine 106.6μmol/L, urine protein 3+ may suggest chronic nephritis, nephrotic syndrome, diabetic nephropathy, urinary stones and other diseases, it is recommended to consult the doctor in time to find out the cause of the disease, and according to the cause of the disease can be taken medication, surgery and other treatment. In addition, attention should also be paid to evaluating the level of glomerular filtration rate of the patient and early detection of renal insufficiency. 1. Chronic nephritis, nephrotic syndrome: due to the impaired glomerular filtration function, renal function decreases, urine protein 3+ and creatinine increase can be seen in the examination. Sartans or prilosec drugs, such as irbesartan, captopril, etc., can be applied to reduce blood pressure and proteinuria; glucocorticoids, immunosuppressants such as prednisone, cyclophosphamide, etc. can be applied for treatment if necessary. 2. Diabetic nephropathy: Diabetic nephropathy causes changes in glomerular function, which impairs glomerular filtration function and reduces renal function, leading to increased urine protein and increased creatinine. Actively control the blood sugar level, can be oral acarbose, metformin, etc., can also apply insulin hypoglycemic treatment. 3. Urinary stones: When urinary stones lead to post-renal obstruction, creatinine increase and protein increase in urine may occur, oral lithotripsy granules can be taken, and extracorporeal shock wave lithotripsy or surgical treatment can be performed if necessary. All the above medications should be used under the guidance of a doctor, avoid self-medication. If you find that creatinine increase and urine protein positive, it is recommended to go to the regular hospital in time, complete the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.