Sudden elevation of glycan antigen CA-125 should firstly improve the examination to clarify the cause, and then review the indicators to observe the changes, symptomatic treatment, surgery, radiotherapy and other therapeutic measures for different causes. Glycoantigen CA-125 is a commonly used tumor marker with normal value <35kU/L. Sudden elevation is considered to be caused by early pregnancy, benign diseases such as pelvic and abdominal tuberculosis, and malignant diseases such as ovarian cancer. 1. Pregnancy: If the pregnancy is in the early stage, it is only necessary to review this indicator regularly to observe the changes, and the indicator can be normalized in the late stage of pregnancy. 2. Benign diseases: if it is pelvic and abdominal tuberculosis, active anti-tuberculosis treatment is needed, and regular monitoring of CA-125 changes; if it is ovarian cysts, polyps and other benign tumors that lead to a sudden rise in the index, small and asymptomatic benign tumors can be followed up for observation and no treatment, but if the benign tumors are too large and cause pain and other discomforts, they need to be removed by surgery in a timely manner. 3. Malignant tumors: If it is malignant tumor such as ovarian cancer, timely surgery, radiotherapy and other anti-tumor treatments are needed. It is recommended that patients further improve the imaging and pathology examination, and actively treat under the guidance of doctors, so as to avoid delaying the condition.