Cryptococcus antigen can be converted, but for immunocompromised people, there is a certain chance of relapse after conversion. Cryptococcus is a kind of fungus, and a positive test result indicates the presence of cryptococcal infection in the patient’s body, which mainly invades tissues and organs such as lungs and meninges, and most of the patients have a poor prognosis, but many of them can be restored to health after treatment. Cryptococcal infection occurs mostly in HIV patients and immunocompromised people. If the patient finds the infection in time, he or she can regain health through effective treatment, and the cryptococcal antigen will become negative after the cryptococcus bacteria are cleared from the body. However, in the case of HIV patients, due to their low immunity, the chances of recurrence of the infection are relatively high, and if the infection is not treated in time, the disease will not be cured, leading to death. However, if there is no other disease, and cryptococcal infection starts slowly, most of these patients can be cured, and the antigen will become negative after the cure, and usually will not recur. Cryptococcal infections mainly target immunocompromised people, so it is very important to improve one’s immunity to prevent this disease. You should pay more attention to exercise, maintain a healthy diet, and avoid smoking and drinking to prevent cryptococcal infections from occurring as a result of lowered immunity.