The third national cause of death survey shows that malignant tumors have become the first cause of death in China’s cities, and the mortality rate of malignant tumors among urban and rural residents in China is at a higher level in the world. Data from the 2012 China Tumor Registry Annual Report shows that the annual number of new tumor cases in China is estimated to be about 3.12 million, with an average of 8,550 people per day, and 6 people are diagnosed with malignant tumors every minute nationwide. The lifetime probability of cancer in China is 22%; the national tumor mortality rate is 180.54/100,000, and it is estimated that there are 2.7 million cases of death due to cancer every year, and the chance of death due to cancer in China is 13%. Lung cancer still ranks first in tumor incidence and death, and the statistics of the American Oncology Society in 2013 showed that lung cancer mortality ranks first among all causes of death from malignant tumors (28% vs. 26%). Chinese medicine plays an important role in lung cancer prevention and treatment. Staged treatment of lung cancer with TCM is the treatment principle of combining TCM with different modern medical treatments to comprehensively control lung cancer according to different stages and treatment phases. As early as more than 300 years ago, Li Zhongzi, a famous medical doctor in the late Ming and early Qing dynasties, proposed the principle of treating malignant tumors (called “accumulation” in the book) in three stages, namely, the beginning, the middle and the end, “The beginning is when the disease starts, and the righteousness is still strong. In the middle stage, the patient is suffering from the disease for a long time, the evil Qi is deeper and the positive Qi is weaker, so the patient is subject to attack and tonic; in the end stage, the patient is suffering from the disease for a long time, the evil Qi is encroaching and the positive Qi is dissipated, so the patient is subject to tonic. In other words, in the early stage, the patient’s righteousness is still strong and can tolerate the attack, such as surgery, radiotherapy, chemotherapy, intervention and other anti-tumor means are all attacking means; in the middle stage, the patient’s physique decreases and cannot be treated with anti-tumor treatment to eliminate the evil, but should combine anti-tumor treatment with corrective treatment; in the end stage, the patient’s physique is poor and cannot tolerate surgery, radiotherapy and other anti-tumor means, so corrective treatment should be the main focus. According to whether lung cancer patients undergo surgery or not, the following is divided into two parts: postoperative patients with TCM phased prevention of recurrence and metastasis and non-surgical patients with TCM phased comprehensive treatment. I. Post-operative patients–stage prevention of lung cancer recurrence and metastasis by Chinese medicine: How to stage in clinical practice? According to the International Union Against Cancer (UICC) TNM staging criteria for lung cancer, there is no survival benefit for postoperative adjuvant chemotherapy in stage IA. Although there is no definite conclusion on whether there is a survival benefit for postoperative adjuvant chemotherapy in stage IB, some scholars believe that adjuvant chemotherapy is beneficial based on the results of relevant studies, especially for those with masses greater than or equal to 4 cm, and for stage II-IIIA and some However, the efficacy of adjuvant chemotherapy is not satisfactory, and the beneficiaries are mainly patients with high performance status scores (PS), i.e., “any-attack” and some “any-attack” patients. The patients who benefit are mainly those with high performance status (PS) scores, i.e., “any-attack” and some “any-attack and tonic” patients. Western medicine has no satisfactory means to prevent and treat postoperative recurrence and metastasis. Chinese medicine has obvious advantages in the prevention and treatment of postoperative recurrence and metastasis in three stages, as follows: 1. The main treatment of Chinese medicine is to restore the patient’s physical strength as soon as possible by identifying the evidence, supporting and cultivating the essence, and “carefully observing where the yin and yang are and regulating them to calm the period”. Although there is a lack of evidence-based medical evidence to confirm the role of this stage in preventing postoperative recurrence and metastasis, the quality of life of patients after Chinese medicine has significantly improved. 2, Western chemotherapy “to get rid of the evil”, Chinese medicine to reduce toxicity and increase the effectiveness of the stage. That is, the postoperative adjuvant chemotherapy stage (for stage IA and some stage IB patients do not need chemotherapy, no such stage), or adjuvant radiotherapy. In this stage, Western chemotherapy is mainly used to remove the evil, and Chinese medicine is used to help reduce the toxicity and increase the efficacy. During the 4 courses of platinum-containing chemotherapy starting around 1 month after surgery, patients mostly show symptoms such as fatigue, weakness of the waist and knees, hair loss, memory loss, etc., which are all signs of deficiency, and usually also have different degrees of gastrointestinal reactions, showing signs of internal disturbance of stomach heat and disharmony of stomach qi. 3, Chinese medicine to support the righteousness and eliminate evil stage – the main stage of anti-relapse and metastasis. Four courses of conventional adjuvant chemotherapy after surgery and western medicine treatment are completed. Although the patient is in complete clinical remission at this stage, the remaining cancer cells in the body will recur or metastasize under certain conditions. Therefore, Chinese medicine is still needed at this stage to support and eliminate the evil and consolidate the treatment. The specific treatment plan is the same as stage IIB-IV NSCLC stage II below. In general, although lung cancer is treated with chemotherapy, interventional or radiotherapy, it is still a long-term process in which evil and good are in competition with each other, and recurrence and metastasis will still occur once the prevention and treatment is not appropriate. In this stage, we focus on helping the positive and eliminating the evil, consolidating the effect of the first two stages of treatment, increasing the body’s anti-cancer power, and at the same time suppressing and killing the cancer toxins that may not be exhausted to prevent the spread, so as to reduce the rate of recurrence and metastasis and prolong the survival period. The efficacy of TCM in preventing postoperative recurrence and metastasis is still lack of evidence-based medical evidence, but clinical research on TCM combined with chemotherapy against postoperative recurrence and metastasis has been widely carried out, which is one of the entry points for future research on the combination of Chinese and Western medicine in preventing and treating lung cancer. In short, the first stage of prevention and treatment of postoperative recurrence and metastasis is based on Chinese medicine “supporting the righteous” to restore patients’ physical strength as soon as possible; the second stage is based on Western medicine adjuvant chemotherapy or chemotherapy combined with radiotherapy “eliminating the evil”, supplemented by Chinese medicine to reduce toxicity and increase effectiveness; the third stage is based on Chinese medicine “supporting the righteous and eliminating the evil”. “This stage is the most important and lasts the longest. It has been reported that long-term oral Chinese medicine treatment can prolong the overall survival of patients with small liver cancer after surgery. At present, it is generally advocated to take Chinese medicine for 3-5 years after malignant tumor surgery, and further clinical evidence is needed to support the specific duration. For patients who refuse surgery or stage IIIB-IV NSCLC patients, Chinese medicine is mostly used in combination with chemotherapy or radiotherapy in a phased manner. In the first stage, chemotherapy or chemotherapy combined with radiotherapy is the main treatment for eliminating evil, supplemented by Chinese medicine to reduce toxicity and increase effectiveness. The second stage is the comprehensive maintenance treatment of Chinese medicine. 1. First-line chemotherapy is usually 4 courses of chemotherapy, and the efficacy is better when supplemented with Chinese medicine to help reduce toxicity and increase effectiveness during chemotherapy. For some patients who are suitable for maintenance chemotherapy, maintenance chemotherapy is started after the first-line chemotherapy; or the disease progresses during the treatment process, the second-line or third-line chemotherapy is used instead, and the treatment time of this stage is extended accordingly; for some patients with EGFR mutation or who refuse chemotherapy, targeted drugs such as Erysal or Trokai are mainly used to “dispel evil”, together with For some patients with EGFR mutation or who refused chemotherapy, the treatment was based on targeted drugs such as Erysal or Trokai, and the combination of the herbs was used to benefit the qi, strengthen the spleen, detoxify and disperse the nodules, and help to dispel the evil to reduce the adverse effects such as diarrhea and rash, and delay drug resistance. 2. Integrated maintenance treatment stage of Chinese medicine. It is also the main stage of anti-growth and metastasis. In this stage, the maintenance treatment is mainly based on the comprehensive Chinese medicine “supporting the righteousness and dispelling the evil”, and the majority of patients are clinically identified as having qi deficiency, so we treat this type and the type of essence and qi deficiency with ginseng and astragalus fuzheng injection + huachansu injection intravenously. Clinical research shows that Ginseng-Qi Fuzheng Injection has the effects of improving immunity, protecting bone marrow function and promoting hematopoiesis, reducing toxic side effects of chemotherapy, and is more effective for patients with Qi deficiency and Yin-Yang deficiency; while Huachansu Injection has anti-cancer effects on lung cancer, liver cancer and other tumors, in addition to reducing symptoms, stabilizing or shrinking lesions, and relieving cancer pain and improving quality of life. For patients with dialectical yin deficiency type, they are treated with raw vein injection or ginseng and wheat injection + huachansu injection by intravenous drip. Depending on the stage of the disease and the results of the dialectical evidence, patients can also choose Kangai Injection, Ginseng Injection, Kanglet Injection, Compound Bitter Ginseng Injection, Addy Injection, Crow’s bile oil cream injection and other Chinese medicine preparations to help fight against cancer. After the chemotherapy is finished, intravenous drip treatment with Chinese herbal injections should be given once a month for 10~14 days each time for a course of treatment, and 4 consecutive courses of treatment are appropriate. During the period of intravenous injection of Chinese herbal medicine, dialectical oral anti-cancer herbal soup is taken, and after 4 courses of intravenous injection of Chinese herbal medicine, oral dialectical herbal soup is continued for 3~5 years to consolidate the maintenance treatment. For patients with higher risk of recurrence and metastasis, oral anti-tumor Chinese medicines, such as Huachansuo tablets, anti-cancer pills, and compound Zebrano capsules, etc., and for those with brain metastasis, oral opium bile oil cream oral solution. In case of disease progression, patients should be treated in phases with radiotherapy and chemotherapy or integrated Chinese medicine according to their condition. For some surgical patients, if the time of waiting for surgery is longer before surgery, they should also be treated with TCM evidence-based anti-tumor therapy in order to control disease progression or reduce the possibility of metastasis, and to provide protection for surgical resection. Although TCM has played an important role in the prevention and treatment of malignant tumors and has a long history, it has been questioned by many Western medical oncologists due to the unclear anti-tumor mechanism of TCM. However, in recent years, with the significant investment in scientific research on TCM for the prevention and treatment of malignant tumors, the number of clinical studies on strictly designed TCM interventions for the treatment of malignant tumors has gradually increased, and the results of more and more clinical trials have shown that comprehensive TCM treatment can improve the disease control rate of lung cancer, prolong the survival period and improve the quality of life. A large number of experimental studies have confirmed that TCM treatment of lung cancer works at multiple levels, links and sites, for example, Lung Yan Ning Fang (composed of Yi Qi, nourishing essence, detoxifying and dispersing herbs) can regulate the expression of tumor growth and metastasis-related genes such as VEGF and HIF, as well as cell cycle-related genes, metabolism-related genes, cellular signal transduction molecules and transcriptional regulatory factors, showing It shows obvious multi-target and multi-pathway anti-tumor and anti-recurrence and metastasis effects. More and more evidence shows that individualized treatment based on evidence-based therapy in TCM has obvious advantages, and the continuation of TCM maintenance and consolidation therapy after surgery, radiotherapy and chemotherapy can effectively prolong the survival and improve the quality of life. Chinese medicine, staged and individualized treatment is an effective method to prevent and treat lung cancer. Staged treatment of lung cancer with TCM should be a rational choice for oncologists and lung cancer patients.