Active SLE usually tends to go into remission after treatment with hormones and other treatments, and turns into the stable phase (remission phase). Because there is no cure so far, the disease changes from the stable phase to the active phase under the influence of certain triggers, such as infection, pregnancy, surgery, exertion and drug withdrawal. Clinically, a patient in remission should be considered to have a relapse of the disease if the following symptoms and abnormalities in laboratory tests occur (1) Fever of unknown origin. That is, the fever cannot be explained by a cold, pharyngeal, pulmonary, or urinary tract infection, and is not due to other diseases; ② fresh rash reappears or is accompanied by vasculitis-like rash on the ends of fingers (toes) or other parts of the body; ③ joint swelling and pain reappears; ④ hair loss is obvious; ⑤ fresh ulcers of the mouth and nose; ⑥ pleural or pericardial effusion appears, ⑦ proteinuria increases; ⑧ leukocytopenia or thrombocytopenia or anemia is obvious; ⑨ neurological symptoms, such as headache, vomiting, convulsions; ⑩ increased anti-double-stranded DNA antibody titer;? Increased blood sedimentation of 50 mm/hour or more;? Decrease in complement, especially C3. Combined with the medical history and detailed physical examination, it is usually not difficult to make a judgment of disease recurrence. Complement C3 and anti-double-stranded DNA antibodies are often laboratory indicators of SLE activity. Therefore, in order to detect changes in the disease in a timely manner, patients with fever should go to the hospital for examination in a timely manner. Doctors ask patients to have regular blood tests for the purpose of early detection of changes in the disease. There are clear reasons for relapse, such as sudden discontinuation or rapid reduction of hormones, or overexertion, sun exposure, etc. In one farmer’s patient, there was a relapse of lupus disease every summer or after the autumn harvest; some relapsed during pregnancy or after giving birth. The causes of relapses are not well understood in some cases. It is important to point out that other diseases must be ruled out in order to have a relapse, and one should not simply consider a positive antinuclear antibody or a non-decreasing antinuclear antibody titer as a relapse, because antinuclear antibodies do not necessarily parallel the disease activity. Nor should headache and vomiting be simply considered as a relapse or exacerbation of lupus or a combination of encephalopathy. A patient who had been ill for many years adjusted her hormones on her own without following medical advice, adding a few hormone pills whenever she had some discomfort. After a headache and vomiting, she increased prednisone to 40 mg daily on her own, not knowing that on the basis of long-term hormone and immunosuppressive drugs for several years, her immune function decreased and she was prone to co-infection, and was confirmed to have cryptococcal meningitis by lumbar cerebrospinal fluid and was hospitalized for up to 8 months.