Wake up at three o’clock (early morning) on the body’s harm, to combine their own health and combine the actual to judge. If according to the biological clock law, and have enough sleep, usually no effect, such as being woken up by the outside world or poor quality of sleep, sleep deprivation or insomnia, long-term three o’clock waking up, will image the human body’s endocrine and nervous system, caused by memory and resistance to decline and other hazards. 1. Under normal circumstances, fewer people will wake up at three o’clock, such as special needs, under the premise of maintaining a normal personal biological clock, with better sleep quality and adequate sleep duration, waking up at three o’clock generally does not have any effect on the human body. 2. If by chance there are few times of being disturbed by external factors, resulting in waking up at three o’clock, if you can remove the interfering factors, continue to sleep or make up for a certain amount of sleep during the day, most of them will not be harmful to the human body. 3. For long-term insomnia, frequent external disturbances, poor sleep quality and other factors, may cause the human endocrine system and nervous system problems, such as endocrine disorders appear dry skin, acne acne; memory loss of forgetfulness, headache, dizziness; resistance to reduce induced respiratory, gastrointestinal and other diseases, but also may cause women to appear menstrual cycle disorders. In daily life, if there is a lack of sleep or other factors lead to wake up at three o’clock, it is recommended to consult a doctor for examination in a timely manner, and standardized treatment under the guidance of the doctor.