Glutamine transaminase has not been able to come down, it may be due to physiological factors such as taking medication and alcohol abuse, or it may be due to hepatobiliary diseases such as alcoholic liver, viral hepatitis, cirrhosis, biliary obstruction and so on. Glutaminase is found in the body mainly in the liver cells and is found in low levels in the serum. When hepatocytes are damaged, glutamine is released from the hepatocytes, causing high levels in the serum. Factors causing hepatocellular damage may be both physiologic and pathologic. 1. Physiological factors: certain bad habits, such as staying up late for a long time, alcoholism, excessive fatigue, etc., will have a certain damage to the liver cells, resulting in ghrelin transaminase has not been reduced. Certain drugs or metabolites can cause damage to liver cells, and if the patient takes these drugs for a long time, it will also make the ghrelin not go down. 2. Pathological factors: mainly alcoholic liver, fatty liver, viral hepatitis, cirrhosis, liver cancer and other liver diseases, will lead to sustained damage to liver cells, so that transaminases are continuously released into the blood, resulting in ghrelin not going down. In addition, diseases of the gallbladder or bile ducts, such as biliary tract obstruction, can affect the excretion of transaminases, which can also keep ghrelin down. If the patient has a long-term glutamine aminotransferase does not go down, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.