The itchy skin on the calves may be caused by eczema, dermatitis or urticaria, which can be treated with medication according to the cause. 1. Eczema is a chronic inflammatory skin disease, mainly related to genetic factors, immune abnormalities, endocrine diseases, environmental factors, diet, mental factors can trigger the disease, mainly manifested as polymorphic rash with obvious itching, the patient can use glycerine lotion, tacrolimus ointment, or pimecrolimus cream for treatment. 2. 2. dermatitis is due to a variety of factors caused by inflammatory skin diseases, mainly related to contact with allergens, genetics, immune abnormalities or skin disorders function abnormality and other factors, mainly manifested as dry skin, itching, the patient can be treated with glycerine lotion, tacrolimus ointment, with oral cetirizine and other antihistamine drugs if necessary. 3. Urticaria is caused by the activation of mast cells leading to the expansion of small blood vessels in the skin and mucous membranes as well as the increase in permeability, mainly manifested in different sizes and shapes of the wind, accompanied by itching, mainly through the oral antihistamine medication, such as cetirizine, loratadine, etc., and the itching is serious with the use of topical glycerine lotion. Itchy calf skin is caused by many factors, it is recommended to go to the hospital for examination and diagnosis in a timely manner, after the cause of the disease is clear, under the guidance of the doctor symptomatic treatment, do not blindly use medication, to avoid misunderstanding the condition of aggravation of the symptoms.