Chronic bronchitis, once diagnosed, is usually not curable. Chronic bronchitis is defined as a course of coughing for more than 3 months per year for more than 2 years, mostly in patients who have been smoking for a long time. The main clinical manifestations are recurrent cough and sputum, even with wheezing. Examination may reveal dry and wet rales in both lungs, and chest imaging may suggest increased and thickened texture in both lungs. Chronic bronchitis can manifest itself clinically as cough, sputum, and wheezing to varying degrees with the change of seasons and with or without smoking cessation. Chronic bronchitis is not curable mainly because the endothelial cells have undergone significant pathological changes, including impaired ciliary oscillation and reduced clearance capacity, which predispose to recurrent respiratory infections. Therefore, once diagnosed, chronic bronchitis cannot be cured, but can only be reduced by quitting smoking, enhancing exercise, and strengthening the immune system to reduce the number of recurrent attacks.