There is no such thing as a toothache’s worst medicine. Toothache is a common cause and many oral diseases can cause it. Doctors clarify the cause of the disease, and then treat the symptoms. Usually, toothache can be caused by caries, pulpitis, apical periodontitis and so on. Filling and root canal treatment should be carried out according to the specific situation, and oral acetaminophen tablets and ibuprofen can be taken to relieve pain if the pain is severe. 1. Caries: Bacterial infection and other causes of tooth hard tissue defects, forming cavities. There may be sensitivity to cold or hot stimulation or pain when food enters the cavity. If there is no invasion of the pulp, the diseased tissue can be removed and then filled. Medications include acetaminophen tablets and ibuprofen tablets. 2. Pulpitis: It is an inflammation that occurs in the pulp tissue. In the acute stage, it can be manifested as severe tooth pain, inability to locate and other symptoms, the pulp can be opened and drained to release the pressure in the pulp cavity, which can relieve the pain. After the acute stage, the infected material in the root canal can be completely removed and perfect root canal treatment can be done. 3. Periapical inflammation: refers to the inflammation that occurs in the periapical tissues. Most of them are developed from endodontic disease, with symptoms such as floating sensation, percussion pain and persistent throbbing pain. In the acute stage, the pulp can be opened and drained for pus drainage, and after the inflammation is controlled, root canal treatment is done. Patients with toothache should consult the doctor in time to clarify the cause of the disease, and treatment under the guidance of the doctor can be used as an adjunctive medicine.