Drug treatment, preventive treatment, surgical treatment and other ways can play a role in promoting bile secretion, but the specific treatment needs to be combined with the patient’s actual disease, in order to carry out symptomatic treatment. Clinical segmental ileitis, chronic hepatitis and other inflammatory diseases are common causes of bile secretion insufficiency, for such diseases need to use antibiotics for anti-infective treatment, such as ticlopidine, lamivudine, mesalazine and so on. For bile deficiency caused by occupying lesions, such as cholangiofibroma, hepatocellular carcinoma, etc., we need to adopt symptomatic treatment by combining with the type of disease and pathological stage of the patient, and the specific treatment modes include surgical treatment and drug treatment. Imbalance of gastrointestinal bacteria and hyperlipidemia can also induce bile insufficiency, for these patients, in addition to receiving standardized medication, they should maintain good living and dietary habits in daily life in order to prevent further deterioration of the condition.