Anisotropic hyperplasia is also called atypical hyperplasia. Many patients with chronic gastritis with atypical hyperplasia are very concerned about the problem of cancer. I have seen many patients who have gone to many hospitals and doctors due to excessive worry and nervousness, and patients who wrongly think that anisotropic hyperplasia is equal to cancer. Therefore, it is necessary to talk about the issue of anisotropic hyperplasia and cancer. In fact, in general, the carcinogenic rate of chronic gastritis is not very high after further development of heterogeneous hyperplasia. There are three degrees of heterogeneous hyperplasia, mild, moderate and severe. Mild and moderate heterogeneous hyperplasia can be reversed with comprehensive treatment, but severe heterogeneous hyperplasia is very dangerous because of its high cancer rate. Some studies show that within 5 years, the possibility of mild heterogeneous hyperplasia turning into moderate and moderate turning into severe is 10% each, while the possibility of severe heterogeneous hyperplasia turning into gastric cancer is 50% to 90% (within 3 months to 2 years), and the reformulation data is available for reference. Therefore, severe heterogeneous hyperplasia should generally be treated immediately and followed up regularly. Of course, sometimes, errors can occur in biopsies of mild and moderate heterogeneous hyperplasia, and some patients have developed cancer but may not be biopsied, so regular checkups play a very, very important role.