What is the effectiveness of ultrasound ablation in treating pancreatic cancer? Many pancreatic cancer patients have asked me this question with questions. Patients with pancreatic cancer will find the answer after reading the following introduction. According to the principle of ultrasound focusing, it generates 70-100 degree high temperature at the focal point (that is, the location of pancreatic tumor), which can inactivate the pancreatic tumor instantly, even if it is close to the blood vessels. Ultrasonic knife treatment is a purely green treatment method without radioactivity, which only inactivates pancreatic tumors through high temperature, with direct and rapid effect. 3 or 4 treatments can relieve the most unbearable pain symptoms of patients and quickly control the development of lesions. This non-invasive treatment method avoids the toxic side effects of radiotherapy and chemotherapy and the accumulation of radioactivity, while avoiding the pain and harm of surgery, especially for patients with deep tumor lesions and those who are not suitable for surgery, such as pancreatic cancer patients. 2. Symptoms of pancreatic cancer: The main symptom of pancreatic cancer is pain, and 85%-95% of these patients who show pain are already inoperable for surgical resection or are in the progressive stage. The main symptom of pancreatic cancer is pain, and 85% of the patients with pain are inoperable or in the progressive stage. 60% to 80% of the patients with pancreatic cancer have pain in the upper abdomen. The pain is usually not related to the diet, and most of them are mild at the beginning, but the pain is persistent and gradually increasing. The degree of pain varies from fullness and distension, dull pain to severe pain. The pain radiates to the right side of the head of the pancreas, while most of the tail cancer radiates to the left side. Pain in the lower back is indicative of a more advanced stage and poor prognosis. In pancreatic cancer, the pancreatic duct may be enlarged by the cancer, which may cause obstruction, dilatation, distortion and pressure increase, resulting in continuous or intermittent distension and pain in the upper abdomen. Sometimes, pancreatitis is also combined with pancreatitis, causing visceral neuralgia. The nerve impulses are transmitted via the visceral nerves to the sympathetic ganglia from T6 to T11, so the early stage of the lesion often presents a wide range of upper and middle abdominal discomfort, vague pain or dull pain, which is not easy to locate and is often aggravated 1 to 2 hours after eating, so the fear of food to reduce the pain aggravated by eating. This is mostly seen in early stage pancreatic head cancer with pancreaticobiliary duct obstruction, which is caused by an increase in bile and pancreatic juice secretion induced by drinking alcohol or eating fatty food, thus causing a sudden rise in pressure in the bile duct and pancreatic duct. Since the pancreas is rich in blood vessels and nerves and adjacent to the retroperitoneal plexus, when the lesion expands and metastasizes and affects the peritoneum, pancreatic head cancer can cause right upper abdominal pain, while cancer of the tail of the pancreatic body is to the left, and sometimes it can involve the whole abdomen. Low back pain is common, and it is more intense in progressive lesions, or it is limited to the bundle of both quarters, suggesting that the cancer metastasizes to the retroperitoneal plexus along the nerve sheath. The abdominal pain of typical pancreatic cancer is often aggravated when lying on the back, especially at night, forcing the patient to sit up or bend forward or bend the knees to relieve the pain, sometimes causing the patient to toss and turn at night, probably due to the infiltration of the cancer and compression of the abdominal plexus. In addition to pain in the middle abdomen or left upper abdomen or right upper abdomen, a few cases complain of pain in the left or right lower abdomen, around the umbilicus or the whole abdomen, and even testicular pain, which can be easily confused with other diseases. When the cancer involves visceral peritoneum, peritoneum or retroperitoneal tissue, there may be pressure pain in the corresponding area. 3.Treatment methods: At present, there is no particularly good method for treating painful pancreatic cancer in internal medicine except anesthetic drugs, and abdominal plexus resection was once the only surgical method, but it is so traumatic that it is not widely used. 4. Effective treatment methods and effects of pancreatic cancer So is there a way to help pancreatic cancer patients relieve pain or relieve pain and provide quality of life without surgery? Yes, ultrasonic local ablation is an effective treatment for pancreatic cancer pain. It can effectively relieve more than 70% of the patients’ pain. It can greatly improve the quality of life of pancreatic cancer patients. Evaluation of efficacy: As the pancreas is a solid organ, its tumor will not shed and shrink immediately after necrosis, so the criteria for judging the efficacy should focus on three major aspects: the ratio of tumor cells killed by heat, laboratory tests and clinical symptoms. Efficacy: 1) pain relief and discontinuation of analgesic drugs; 2) ultrasound showed that all tumor echogenicity was enhanced or liquid dark area appeared, or CT showed ablation foci or significant reduction or disappearance of tumor volume; 3) multi-point puncture showed that most cells were necrotic; 4) PET-CT examination showed that phosphodiesterone (PDE) in the tumor area did not appear; 5) quality of life score improved significantly.